An Airbus A380 flew almost an entire flight with a hole in it's side.

Here is a link to an article giving the details and has images of the aircraft. This was a flight to Australia that flew for about 13 hours with a huge hole in the side of the airplane. It is an Airbus A389, one of the largest passenger planes in the world.

http://avherald.com/h?article=4fb1cbea